Commercial manufacturing processes in bioprocessing

The step up from the research and development stages of drug development to commercial manufacturing ensures the public has access to the effective drug product you’ve worked tirelessly for years to produce. So, what are the ins and outs of commercial manufacturing?

Continue reading our latest blog to find out what commercial manufacturing processes in bioprocessing entail and how bioprocess containers can benefit your operations.

What are commercial manufacturing processes in bioprocessing?

Commercial manufacturing in bioprocessing is the large-scale production of bioprocessed goods for public use, including biopharmaceuticals such as vaccines, monoclonal antibodies, and food products.

Scaling up small laboratory operations for industrial manufacturing is essential to ensure global demand is met and that products are consistent and compliant with strict regulations, such as Good Manufacturing Practice (GMP). Cost-effective production methods are another hallmark of commercial bioprocess manufacturing and are vital from a business point of view. 

Vaccine manufacturing processes

Vaccine manufacture is the regulated procedure of producing vaccines, which are biological products that stimulate the immune system to fight off specific diseases. Unlike during pilot manufacturing, commercial processes produce large batches of vaccines ready to be distributed to healthcare providers and vaccination programs worldwide. 

Dr Lewis Vaschetto ph.D. writes that ‘the effectiveness of vaccines as a public health tool relies on their widespread administration to large populations’. This is why commercial pharmaceutical manufacturing is imperative, as it ensures that the demand for potentially life-saving vaccines is met and that their effects are felt.

But how exactly does the vaccine manufacturing process work? Well, this is an industrial scale-up of the pilot vaccine production methods used to develop the approved vaccine. This product must adhere to strict regulations of quality, potency and purity. 

The manufacturing process often involves:

• Cultivation – Antigen cultivation using cell cultures or recombinant DNA technology to develop high-quality antigens.
• Purification – The antigens undergo a purification process that aims to optimise them while removing unwanted debris and impurities to boost their effectiveness and improve their safety for consumption. Filtration and chromatography are examples of purification techniques utilised by biomanufacturers.
• Formulation – The purified antigens are combined with adjuvants, stabilisers and preservatives to stimulate an effective and long-lasting reaction and maintain the vaccine’s efficacy during storage and transportation. This stage also ensures that it remains stable and safe for administration.

Food bioprocessing and commercial manufacturing

The food industry utilises commercial manufacturing to produce some of our most-loved consumables, such as bread and wine (this is actually where bioprocessing originated from). Bioprocesses such as fermentation, which is used to create foods including sourdough bread, can be completed on a large scale to fulfil the demands of the market. 

In commercial biomanufacturing, using organic processes to make food and drink products can also help to improve quality and taste, increase product yield, enhance nutritional value and provide better food preservation.

How bioprocess containers can benefit commercial manufacturing

Bioprocess containers are effective fluid-management systems utilised across various commercial manufacturing applications and industries that use bioprocessing. These units are designed to store bioprocess bags containing liquids required during biomanufacturing processes.

During industrial-scale vaccine production, bioprocessing containers house biofluids such as the culture media and bioreactor feeds needed to develop the antigens. 

At ALLpaQ, our state-of-the-art systems are designed to enhance your commercial operations and keep your facility hygienic and sterile. Bioprocess containers from our vast range offer the following benefits:

• Enhanced hygiene – Complete with smooth poly walls that inhibit bacterial growth and are easy to clean, our design will help to keep your operations sterile and free from contamination. 
• Elite-quality – As an ISO 9001-certified company, you can rely on our products to deliver a fantastic performance throughout their long life cycle and never let you down. Expert manufacturing combined with an impressive strength-to-weight ratio means your container will shield your media with ease.
• Customisability – Our systems can be tailored to your exact fluid-handling needs, so you won’t struggle to find a model for your unique applications.
• Storage – Thanks to their palletted base, our bioprocess containers can be stacked seamlessly in warehouses. They can also be effortlessly collapsed and folded away, freeing up more precious floor space.
• Compatibility – Our modern container systems are fully compatible with all plastic media bags.
• Sustainability – We have 14001 certification, a gold Evovadis rating, and a BCorp certification. Here, at ALLpaQ, we also offer a ‘rent a tote’ service to improve the positive impact on the environment with a circular economy.

Contact the ALLpaQ team

Eager to update your facility’s fluid-handling apparatus? If so, you’ve come to the right place!

Our specialists are on hand to help you find your ideal liquid-management solution from our impressive range of bioprocess containers, or design a customised system that specifically caters to your specifications.

For more information or to request a quote, feel free to give our helpful team a call today on 01472 800 373 or contact us online, and we’ll respond as soon as we can. 

Author

Niamh Allen

As a dedicated and detail-oriented Marketing Assistant, Niamh brings a strong passion for creativity and analytics to the marketing team.

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